Signals disappearing some time after changing MEA

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Signals disappearing some time after changing MEA

Post  mcs on Wed Jun 11, 2008 10:04 pm

I use multielectrode arrays to record signals from cultured neurons.

I have a problem recently. When I start recording from a new MEA I get proper electrical signals for the first 10-15 minutes . After that the MEA no longer detects signals , and a constant noise appears throughout the channels which is same in all channels.
Again if I change MEA manually or by using MEAselect->change MEA option the normal electrical signals from the neurons reappaear which again lasts for 10-15 minutes and disppear again giving a noise which is same in all channels . The amplitude of this noise as such is not high. It is of the same amplitude as that I was getting when I was getting the proper electrical signals from neurons.

I would be extremely thankful if you could identify the problem and suggest any possible solutions.

thanking you

Gireesh

mcs

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Re: Signals disappearing some time after changing MEA

Post  mcs on Wed Jun 11, 2008 10:04 pm

Dear Gireesh,

can you send us a screenshot of the noise you observe to support@multichannelsystems.com ? That would really help us to get an idea what might be the source of the problem.

Thank you

Thomas

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