Discriminate Inh. from Exc. Neurons?

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Discriminate Inh. from Exc. Neurons?

Post  jerome1 on Fri Jul 26, 2013 3:04 am

Dear MCS members and users,
I am trying to discriminate excitatory and inhibitory neurons from the shape of their spikes following detection on 8x8 MEA and sorting. Unfortunately, there is nothing conclusive without looking at autocorrelogrammes. Does someone of you have a good method?
Thank you very much.
Jerome

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Re: Discriminate Inh. from Exc. Neurons?

Post  Thomas on Thu Aug 01, 2013 7:58 pm

Dear Jerome,

functionally the spikes are just like biological triggers. as the MEA system can only detect voltage differences between the electrode close to the spiking neuron and a reference electrode, we can not obtain functional information solely from the shape of the spike. I suggest rather to characterize your neurons by pharmacological tools and their indluence on spike rate rather than purely based on spike shape.

Greetings

Thomas

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